The Results of Pregnancy in Ladies with Without Treatment Epilepsy

Highlights: Some ladies with epilepsy cease AED treatment quickly previously and during pregnancy. Some others have taken no AEDs given that well before pregnancy. Seizure control was even worse if seizures happened in pre-pregnancy year. Excepting VPA and TPX, preventing AEDs does not lower malformation threat. Abstract: Function: To determine the outcomes in regards to seizure control and foetal malformation in pregnant ladies with epilepsy not treated with antiepileptic drugs (AEDs). Method: Analysis of information from the Australian Register of AEDs in Pregnancy on 148 women with epilepsy who were not getting AEDs before and during at least the first trimester of pregnancy. Results: Seizure control was less likely to be preserved in AED-untreated pregnancies. Whether AED treatment had been stopped in preparation for pregnancy, or had actually not been used for long periods prior to pregnancy, made no statistically substantial difference to seizure control outcomes, but those who ceased treatment in preparation for pregnancy were more likely to again be taking AED treatment by term. Foetal malformation rates were reasonably similar in without treatment pregnancies, and in treated pregnancies if pregnancies exposed to recognized AED teratogens (valproate and most likely topiramate) were excluded from consideration. Conclusion: Leaving epilepsy untreated during pregnancy appears disadvantageous from the viewpoint of seizure control: it likewise does not minimize the danger of foetal malformation unless it prevents valproate or topiramate consumption throughout pregnancy.

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